ea0029p827 | Endocrine tumours and neoplasia | ICEECE2012
Sbiera S.
, Dexneit T.
, Schmull S.
, Voelker H.
, Kraus L.
, Steinhauer S.
, Allolio B.
, Fassnacht M.
In recent years, it was demonstrated that tumor infiltrating and circulating regulatory and cytotoxic T-cells are associated with clinical outcome in several solid tumors. However, their role in adrenocortical carcinoma (ACC) was never studied, although 60% of these tumors secrete autonomously cortisol, a well-established potent immunosuppressant that most likely influences the balance between different T-cells.Firstly, we analyzed the circulating regula...